Oxytocin attenuates beta oxidation and fatty acid synthesis through CPT1α and FABP4 (605.8)
نویسندگان
چکیده
منابع مشابه
Impact of unusual fatty acid synthesis on futile cycling through beta-oxidation and on gene expression in transgenic plants.
Arabidopsis expressing the castor bean (Ricinus communis) oleate 12-hydroxylase or the Crepis palaestina linoleate 12-epoxygenase in developing seeds typically accumulate low levels of ricinoleic acid and vernolic acid, respectively. We have examined the presence of a futile cycle of fatty acid degradation in developing seeds using the synthesis of polyhydroxyalkanoate (PHA) from the intermedia...
متن کاملFABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes
Fatty acid binding protein 4 (FABP4), plays key role in fatty acid transportation and oxidation, and increases with leptin synergistically during adipose inflammation process. However, the regulation mechanism between FABP4 and leptin on mitochondrial fatty acid oxidation remains unclear. In this study, we found that FABP4 reduced the expression of leptin, CPT-1 and AOX1 in mice adipocytes. Con...
متن کاملMalonyl-CoA: the regulator of fatty acid synthesis and oxidation.
In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. S...
متن کاملThe ratio of acetyl-CoA versus free CoA tightly regulates glycolysis and fatty acid oxidation. Malonyl-CoA attenuates fatty acid oxidation by inhibiting acyl-CoA trans- port into the mitochondrion for oxidation and is utilized in fatty acid synthesis
This article is available online at http://www.jlr.org Acyl-CoAs are a class of important molecules that play essential roles in many physiological processes ( 1 ), such as fatty acid oxidation, lipid synthesis/remodeling, ketone body synthesis, xenobiotic metabolism, and signaling pathways. Classically, acyl-CoAs such as free CoA, acetyl-CoA, and malonyl-CoA are recognized as regulators of met...
متن کاملProcessivity and fatty acid oxidation.
446 TDRAs, through the partial and group response coefficients, confirm that, under every condition that we have studied, malonyl-CoA exerts its effects over the pathway via CPT I. These conclusions apply only to our system and our conditions. Yet our TDCAs in a more physiological system, including ketone body and ATP synthesis in coupled mitochondria, show that in state 3 CPT I has most of the...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.605.8